Cross-reactivity for different type A influenzaviruses of a cloned T-killer cell line
Identifieur interne : 002817 ( Main/Exploration ); précédent : 002816; suivant : 002818Cross-reactivity for different type A influenzaviruses of a cloned T-killer cell line
Auteurs : Lin Yun Lu ; Brigitte A. AskonasSource :
- Nature [ 0028-0836 ] ; 1980-11-13.
Abstract
Spleen cytotoxic T cells killing influenza virus-infected target cells are cross-reactive for the different type A influenza viruses, in contrast to the circulating antibodies, which show fine specificity for each A virus subtype variant1,2. This finding has raised the question of whether a single T cell can recognize cells infected with all the type A viruses. T-killer cell lines with specificity for alloantigens and the male Y antigen can be selected by means of growth factors present in the supernatant of T cells stimulated with concanavalin A (refs 37). We report here that we have been able to establish clones of mouse T cells killing target cells infected with influenza virus. Our cell line maintains the same specificity as the heterogeneous spleen cell population from infected mice, in as far as the T-killer cells are specific for A influenza virus, but do not discriminate between the different type A viruses. The cell line maintains H2 restriction and does not kill cells infected with B influenza virus. The cells grow in the presence of T-cell growth factor and do not require antigen for growth although they maintain their receptors for type A virus. They can also be stimulated by irradiated T-helper cells from mice primed by type A influenza infection in the presence of type A virus-infected cells.
Url:
DOI: 10.1038/288164a0
Affiliations:
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viruses of a cloned T-killer cell line</title><author><name sortKey="Lu, Lin Yun" sort="Lu, Lin Yun" uniqKey="Lu L" first="Lin Yun" last="Lu">Lin Yun Lu</name><affiliation><wicri:noCountry code="subField">addressed.</wicri:noCountry></affiliation></author><author><name sortKey="Askonas, Brigitte A" sort="Askonas, Brigitte A" uniqKey="Askonas B" first="Brigitte A." last="Askonas">Brigitte A. Askonas</name></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1980-11-13">1980-11-13</date><biblScope unit="vol">288</biblScope><biblScope unit="issue">5787</biblScope><biblScope unit="page" from="164">164</biblScope><biblScope unit="page" to="165">165</biblScope><date type="Copyright" when="1980">1980</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Spleen cytotoxic T cells killing influenza virus-infected target cells are cross-reactive for the different type A influenza viruses, in contrast to the circulating antibodies, which show fine specificity for each A virus subtype variant1,2. This finding has raised the question of whether a single T cell can recognize cells infected with all the type A viruses. T-killer cell lines with specificity for alloantigens and the male Y antigen can be selected by means of growth factors present in the supernatant of T cells stimulated with concanavalin A (refs 37). We report here that we have been able to establish clones of mouse T cells killing target cells infected with influenza virus. Our cell line maintains the same specificity as the heterogeneous spleen cell population from infected mice, in as far as the T-killer cells are specific for A influenza virus, but do not discriminate between the different type A viruses. The cell line maintains H2 restriction and does not kill cells infected with B influenza virus. The cells grow in the presence of T-cell growth factor and do not require antigen for growth although they maintain their receptors for type A virus. They can also be stimulated by irradiated T-helper cells from mice primed by type A influenza infection in the presence of type A virus-infected cells.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Askonas, Brigitte A" sort="Askonas, Brigitte A" uniqKey="Askonas B" first="Brigitte A." last="Askonas">Brigitte A. Askonas</name><name sortKey="Lu, Lin Yun" sort="Lu, Lin Yun" uniqKey="Lu L" first="Lin Yun" last="Lu">Lin Yun Lu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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